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[An overview of the]    

 Tetracaine hydrochloride is a highly effective local anesthetic that reversively blocks nerve function. It is clinically used in infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthetic effect is remarkable, and it has been widely used in clinical practice.  It is found that the synthesis of p-butaminobenzoic acid is the key step in the synthesis of tecaine hydrochloride, which has the disadvantages of unstable raw materials and low yield.  In 1981, the scientists proposed the alkylation reaction of p-aminobenzoic acid and ** to synthesize p-butaminobenzoic acid. However, due to the generation of dibutyl by-products cannot be avoided, and the unstable nature of the raw material itself, this route is not suitable for industrial production.  

[Indication]  

 Tetracaine hydrochloride is used for mucosal surface anesthesia, conduction anesthesia, epidural anesthesia and subarachnoid anesthesia.  It is used for ophthalmic surface anesthesia without constricting blood vessels, damaging corneal epithelium and raising intraocular pressure.  

[usage]  

 This product is a long-acting ester local anesthetic, which is characterized by strong penetration of mucous membrane, suitable for surface anesthesia, without vasoconstriction, dilated pupil, corneal injury and other adverse reactions after eye drop, and is often used in ophthalmology.  The effect and toxicity of local anesthesia were about 10 times more than that of procaine.  After injection, the anesthetic effect appeared slowly (about 10 minutes), the metabolism after absorption was also slow, and the time of local anesthesia was up to 3 IJ, H, -j.  The left and right sides.  It is mainly used for superficial anesthesia of eye, nose and throat mucosa, but rarely for conduction anesthesia and epidural anesthesia.  Because of toxicity, generally not used for infiltration anesthesia.