4-Amino-3,5-dichloroacetophenone

Product Details

Purpose 1
It is an intermediate of the drug clenbuterol
Usage 2
This product is an intermediate of the synthetic cough and asthma suppressant Kechuansu.
Preparation method
Method 1
It is obtained by chlorination of p-amino Acetophenone. Add p-amino Acetophenone and acetic acid (80%) into the reaction pot, stir and dissolve them, quickly add the glacial acetic acid solution containing chlorine, and the feeding temperature is 5 ℃. After the addition, immediately put them into the ice water to precipitate, filter, and wash them. The crude product obtained is recrystallized with ethanol to obtain the finished product.
Upstream and downstream product information
Upstream raw materials
4-Amino Acetophenone acetic anhydride Chloroacetyl chloride 2,6-dichloroaniline 2,4,6-trichloroaniline
Downstream products
1- (4-amino-3-chlorophenyl) - ethanone clenbuterol hydrochloride 3,4,5-neneneba trichlorobenzoic acid 3 ', 5' - dichloroacetophenone
Frequently Asked Questions List
purpose
3,5-Dichloro-4-amino Acetophenone is a cream colored crystal and can be used as a pharmaceutical intermediate.