BOLDENONE CYPIONATE

Product Details

brief introduction
Boldenone cyclopropionate (Bc for short), an androgen anabolic steroid, is one of the esters of boldenone. Boldenone cyclopentanoic acid ester is one of the most common anabolic androgen steroids used by bodybuilders and athletes for non-medical reasons in recent years.
application
Baodanone can be made into different forms of esters. Although the basic drug Baodanone is the same, the esters attached to it can alter the metabolism of Baodanone in vivo. Synthetic metabolic androgen steroids are often esterified to extend the duration of hormone action through intramuscular or subcutaneous injection. The longer ester chain will have a longer half-life, so the esterified boldenone will have a half-life of several hours, while the half-life of boldenone cyclopentanoic acid ester will reach several weeks.
compound
A high yield synthesis method of Baodan ketone using ester formed by acyl chloride and methanol as a protective agent and selecting a better catalyst, as follows:
1. Etherification reaction:
In a stirred reactor, add anhydrous ethanol, triethyl orthoformate, and then add 1.4 ° C while stirring ADD, stir for 5 minutes; Adjust the temperature inside the reaction kettle to 39-42 ℃, then add pyridine bromate, react for 8 hours, add triethylamine, cool to 0-5 ℃, and stir for 1 hour with insulation. When the reaction solution reaches neutrality, it freezes and crystallizes at 0 ± 2 ℃. Wash the obtained etherified product slightly with anhydrous ethanol, shake and filter to obtain a wet etherified product. The anhydrous ethanol, triethyl orthoformate, and 1.4 The weight ratio of ADD, pyridine hydrobromide, and triethylamine is 60-65:40-45:60-80:0.1-0.5:0.5-1.5; The weight ratio of anhydrous ethanol used for slightly washing the etherified product to the etherified product obtained is 70-80:90-100.
2. Reduction hydrolysis reaction:
In the reaction pot, first add methanol, start stirring, then add etherified substances, pyridine, and cool to -2~2 ℃; Add sodium borohydride under stirring, within 1 hour, at -2~2 ℃, and conduct insulation reaction for 1 hour. Perform thin plate chromatography; After the reduction reaction is completed, adjust the temperature to 10 ± 5 ℃, add 36% hydrochloric acid, adjust the PH to about 2.0, concentrate to a thick slurry, pour 350~400L water, and cool to 0~5 ℃; Centrifuge to obtain the reduced hydrolysate, i.e. crude boldenone, and dry it. The weight ratio of methanol, ethers, sodium borohydride, hydrochloric acid, and water input is 65-70:7-8:0.5-1:5-10:35-40; The dropping speed of hydrochloric acid shall be subject to the fact that the material does not explode, and the temperature shall not exceed 20 ℃. After the dropping of hydrochloric acid is completed, the temperature shall be adjusted to 10-20 ℃, and the heat preservation reaction shall be conducted for 1 hour.
3. Refining of crude products:
Put crude boldenone, methanol and water into the reactor; Steam heating, reflux for 1 hour, cool to 0-5 ℃, centrifuge. The weight ratio of boldenone, methanol and water input is 60~65:95~105:35~45. Boldenone can be further reacted with boldenone cyclopentanoic acid ester.
biological activity
Boldenone Cypionate is a steroid that synthesizes and metabolizes androgens