ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate

Product Details

brief introduction
The trade name of N - (1- (phenyl Acetyl group) - L-prolyl) glycine ethyl ester is NOOPEPT, which is used to treat obesity, Alcohol dependence degeneration or toxic injury and other diseases.
biological activity
Omberacetam (GVS-111) is a peptide that can be used as a dietary supplement.
In vitro research
Nooglutil exhibits pharmacologically significant competition with a selective antigen of AMPA receivers ([G-3H] Ro 48-8587) for the receiver binding sites (with IC50=6.4+/-0.2 microM), while the competition of noopeept for these receiver binding sites was lower by an order of magnitude (IC50=80+/-5.6 microM) [1] GVS-111 significantly increased neurological survival after H (2) O (2) - treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC (50) value of 1.21+/-0.07 microM GVS-111 involves the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H (2) O (2) or FeSO (4), suggesting an antioxidant mechanism of action [2]
In vivo research
N-Phenylacetyl-L-prolylglycine ether ester (GVS-111) administered intravenously at a dose of 0.5 mg/kg/day, for the first time 1 hour after ischaemic region and then for 9 pos