Levamisole hydrochloride

Product Details

Purpose 1
Suitable for repelling roundworm, hookworm, and Malay filarial infections
Usage 2
As a Anthelmintic, it is suitable for the treatment of animal roundworm, hookworm, etc.
Usage Three
This product is an intestinal worm repellent. The activity of Levamisole is about twice that of racemate, and its toxicity and side effects are also low. Levamisole can paralyze the muscles of ascaris lumbricoides and excrete them with feces. Mainly used for resisting roundworms and hookworms.
Method 1
It is obtained from racemic tetraimidazole as raw material through separation, alkali precipitation, and acidification to form a salt.
Boil dibenzoyl-D-tartaric anhydride in water for 40 min, neutralize it with sodium hydroxide solution to PH7.5 after hydrolysis, and add racemic tetraimidazole. Levamisole and dibenzoyl Tartaric acid form salts and precipitate. After separation, add sodium hydroxide solution to PH=9 to decompose Levamisole. Then dissolve in a dilute hydrochloric acid solution, decolorize with activated carbon, concentrate the filtrate to near dryness, add acetone to cool to 0 ℃, and precipitate crystals. Filter and dry to obtain Levamisole hydrochloride.
Method 2
Obtained from racemic tetraimidazole (C11H12N2S, [5036-02-2]) separation, alkali precipitation, and salt formation. Boil dibenzoyl-D-tartaric anhydride with water and hydrolyze for 40 min. Lower the temperature to about 45 ℃, adjust the pH to 7.5 with sodium hydroxide solution, and add racemic tetraimidazole. After half an hour of heat preservation, it is cooled to 10 ℃, filtered and washed to obtain Levamisole p-nenenebb benzoyl Tartaric acid. Adjust pH to 9 with sodium hydroxide solution, filter, and wash with water to obtain Levamisole. Adjust the pH to 3-4 with hydrochloric acid, decolorize with activated carbon, filter, concentrate the filtrate to dryness, and cool to 0 ℃ with acetone. Precipitation crystallization. Filter and dry to obtain Levamisole hydrochloride. When separating p-benzoyl Tartaric acid d-imidazole salt, the mother liquid obtained is the mixture of d-imidazole free base, and racemization is carried out to obtain racemic tetraimidazole. Racemic tetraimidazole can also be resolved by p-toluenesulfonylglutamic acid or d-neneneba camphor sulfonic acid.