Product Name: Ethyl 2-phenylacetoacetate
English synonyms:2-Phenylacetoaceticacidethylester;ETHYL3-OXO-2-PHENYLBUTANOATE;ETHYL2-PHENYLACETOACETATE;(2R)-3-oxo-2-phenylbutanoicacidethylester;highquality2-PHChemicalbookENYLACETOACETATECAS5413-05-8;Benzeneaceticacid,.alpha.-acetyl-,ethylester;2-Phenyl-3-oxobutanoicacidethylester;2-Phenyl-3-oxobutyricacidethylester
Boiling point:140-144°C 10mm
Density:1,085 g/cm3
Purity:99%
Usage.
Ethyl 2-phenylacetoacetate, also known as ethyl α-phenylacetoacetate, is an important pharmaceutical chemical raw material, mainly used in the synthesis of the fourth and fifth generation of new cephalosporin antibiotics indispensable intermediates.
Application.
As an ester organic matter, 2- phenyl acetoacetate can be used as an intermediate in medicine.
Production.
(1) a mixture of ethyl acetoacetate and toluene was prepared in a certain proportion, and then the mixture and iodobenzene were injected into the micro-channel reactor by a metering pump at a certain proportion of flow rate, and the discharge temperature of the reactor was controlled at 5 ~ 10ºC. Then the prepared saturated salt water and reaction liquid are mixed continuously stratified, the lower layer is the reaction liquid, the upper layer of salt water. (2) Under atmospheric pressure, the reaction liquid after washing is slowly heated up. When the bottom temperature of the kettle reaches 55ºC, the Chemicalbook is opened and toluene begins to be steamed out. When the temperature of the kettle reaches 100ºC (to ensure the solvent is completely steamed out), the heating is stopped and the distilled solvent is collected and cooled. (3) After recovery of solvent, under vacuum degree -0.1MPa, decompress-distillation, slow temperature, when the temperature of the kettle 85 ~ 90ºC, control reflux ratio of 4, began to steam out of finished products, when the temperature of the kettle rose to 120ºC, stop heating, and turn off the vacuum pump, qualified product 2-phenyl ethyl acetoacetate, and measured its chromatographic content.
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