28578-16-7 pmk ,bmk ,bdo cas 110-63-4,xylazine, 79099-07-3, 79-03-8
Details
Origin: China
Purity: 99.9%
Packing: as requirements
Storage: Dry and cool place and keep away from strong light
Sample: Available
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Metformin HCl is a medication that is often prescribed to treat diabetes. It is used for decreasing blood sugar levels in people with type 2 diabetes. Metformin HCl is an abbreviation for metformin hydrochloride.
The medication works in several ways. It reduces the amount of sugar made by the liver, limits the amount of sugar absorbed into the body from the diet, and makes insuli receptors more sensitive (helping the body respond better to its own insuli). All of these effects cause a decrease in blood sugar levels.
Metformin hydrochloride is a biguanide oral hypoglycemic agent , also known as Glucophage, its hypoglycemic effect is weaker than phenformin, the main role is to reduce the glucagon secretion of A cells ,and to promote the conversion of glucose to glycogen, its characteristic effect including that it does not stimulate pancreatic β-cells to secrete insulin .
The follows are hypoglycemic mechanisms:
1. Increasing the sensitivity of peripheral tissues to insulin, increase insulin-mediated glucose utilization.
2. Increasing glucose utilization of non-insulin-dependent tissues, such as brain, blood cells, kidney medulla, intestine, skin and so on.
3. Inhibiting hepatic gluconeogenesis effect , reducing hepatic glucose output.
4. Inhibiting glucose uptake by intestinal cells.
5. Inhibiting the biosynthesis and storage of cholesterol , lowering blood triglycerides and total cholesterol levels.
Metformin hydrochloride is clinically used for the treatment of type diabetes patients who are not satisfied with simple diet control, especially patients with obesity and hyperinsulinemia, usage of this drug not only displays no hypoglycemic effect, but also there may be weight loss and hyperinsulinemia effect. For some patients with poor efficacy of sulfonylurea ,it may be effective, if it is used with hypoglycemic drugs including sulfonylurea, intestinal glucosidase inhibitors or thiazolidinediones, the results are better than used alone. It can also be used in patients with insulin therapy to reduce the amount of insulin.
Metformin is the first-line medication for the treatment of type 2 diabetes.This is particularly true in people who are overweight. It is also used in the treatment of polycystic ovary syndrome.Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.It is not associated with weight gain.It is taken by mouth.
Product name: | metformin |
Molecular formula: | C4H11N5 |
Molecular weight: | 129.16400 |
Precise quality: | 129.10100 |
PSA: | 88.99000 |
LOGP: | 0.25650 |
Density: | 1.28 g/cm3 |
Boiling point: | 224.1ºC at 760 mmHg |
Flash point: | 89.3ºC |
Metformin is a biguanide oral hypoglycemic drug. It can promote the uptake of glucose by adipose tissue, increase the anaerobic digestion of muscle tissue, increase the utilization of glucose, reduce insulin resistance, reduce the absorption of glucose through the digestive tract, and reduce blood sugar. It is used for adult non insulin dependent diabetes mellitus and partially dependent diabetes. For the majority of juvenile diabetes and lean diabetes that are ineffective after sulfonylurea treatment, this product can also reduce blood sugar. Clinically, it can be combined with sulfonylureas or insulin to enhance its hypoglycemic effect. Obese patients can also lose weight with this product.
Specifications (USP) | Specifications (AJI) | |
Description | White crystals or crystalline powder | White crystals or crystalline powder |
Identification | Infrared absorption spectrum | Infrared absorption spectrum |
Specific rotation | +26.3 °- +27.7° | +26.9 °- +27.9° |
[a]D20° | ||
State of solution | --- | ≥ 98.0% |
/Transmittance | ||
Chloride (Cl) | ≤ 0.05% | ≤ 0.020% |
Ammonium (NH4) | --- | ≤ 0.02% |
Sulfate (SO4) | ≤ 0.03% | ≤ 0.020% |
Iron (Fe) | ≤ 0.003% | ≤ 10PPm |
Heavy metals (Pb) | ≤ 0.0015% | ≤ 10PPm |
(As2O3) | --- | ≤ 1PPm |
Other amino acids | --- | Chromatographically not detectable |
Loss on drying | ≤ 0.5% | ≤ 0.5% |
Residue on ignition | ≤ 0.3% | ≤ 0.10% |
(sulfated) | ||
Assay | 98.5-101.5% | 99.0 - 101.0% |
PH | --- | 10.5-12.0 |
Organic volatile impurities | Meets the requirements | --- |
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