Pharmaceutical Powder Xylazine HCl/Xylazine Hydrochloride/Xylazine CAS 7361-61-7 CAS 23076-35-9

Product Details

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US market very popular ! --_-- Xylazine Crystal & Powder (HCL and Base)

Product Description

Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor. It is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.
Xylazine is often used for veterinary anesthesia.

Product Name:	Xylazine
Synonyms:	2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine;5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine;2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine;Xylazine Base & HCL;Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride;Xylazine (200 mg)
CAS:	7361-61-7
MF:	C12H16N2S
MW:	220.33
EINECS:	230-902-1
Product Categories:	7361-61-7
Mol File:	7361-61-7.mol

 

Application :

Xylazine is often used as a sedative, muscle relaxant, and analgesic. It is frequently used in the treatment of tetanus.Xylazine is very similar to drugs such as phenothiazine, tricyclic antidepressants, and clonidine. As an anesthetic, it is typically used in conjunction with ketamin.Xylazine appears to reduce sensitivity to insuli and glucose uptake in humans.Yohimbine, an α2 adrenergic receptor antagonist, has been used to decrease glucose levels to a healthy level. In clinical settings, yohimbine can reverse the adverse effects of xylazine if administered intravenously shortly after xylazine administration.

Xylazine Side effects:

Xylazine overdose is usually fatal in humans. Because it is used as a drug adulterant, the symptoms caused by the drugs accompanying xylazine administration vary between individuals.

The most common side effects in humans associated with xylazine administration include bradycardia, respiratory depression, hypotension, transient hypertension secondary to vagus nerve stimulation, and other changes in cardiac output. Xylazine significantly decreases heart rate in animals that are not premedicated with medications that have anticholinergic effects. The decrease in heart rate directly impacts aortic flow.[1] Bradycardia caused by xylazine administration is effectively prevented by administration of atropine or glycopyrrolate.Arrhythmias associated with xylazine includes other symptoms such as sinoatrial block, atrioventricular block, A-V dissociation, and sinus arrhythmia.

Xylazine administration can lead to diabetes mellitus and hyperglycemia. Other possible side effects that can occur are areflexia, asthenia, ataxia, blurred vision, disorientation, dizziness, drowsiness, dysarthria, dysmetria, fainting, hyporeflexia, slurred speech, somnolence, staggering, coma, apnea, shallow breathing, sleepiness, premature ventricular contraction, tachycardia, miosis, and dry mouth.Rarely, hypotonia, dry mouth, urinary incontinence and nonspecific electrocardiographic ST segment changes occur. It has been reported that the duration of symptoms after human overdose is 8-72 hours.Further research is necessary to categorize the side effects that occur when xylazine is used in conjunction with heroi and cocai.

Chronic use is reported to be associated with physical deterioration, dependence, abscesses, and skin ulceration, which can be physically debilitating and painful.Hypertension followed by hypotension, bradycardia, and respiratory depression lower tissue oxygenation in the skin. Thus, chronic use of xylazine can progress the skin oxygenation deficit, leading to severe skin ulceration.Lower skin oxygenation is associated with impaired healing of wounds and a higher chance of infection.The ulcers may ooze pus and have a characteristic odor.In severe cases, amputations must be performed on the affected extremities.

Tips: hcl soluble in water, base insoluble in water. (Some Base dissolves in hot water!)
Local anesthesia strength: (The anesthesia effect of some base is stronger than hcl)

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Applied Research and Synthetic Method of Xylazine Hydrochloride

Applications
Xylazine hcl has emerged as a recreational drug recently, especially in the US market.
Alpha2-adrenoceptor agonists, sedatives, and muscle relaxants.
 

Introduction

Xylazine hydrochloride is a sedative veterinary drug. A class of drugs that can slightly inhibit the central nervous system and weaken functional activities, thereby eliminating restlessness and restoring tranquility. In recent years, individual livestock breeders, driven by economic interests, have added such drugs in the process of raising livestock and poultry without authorization to play the role of sedation and hypnosis, weight gain and fattening, and shortening the time for slaughter.

In addition, in the process of animal transportation, in order to reduce animal death and weight loss, and prevent the reduction of meat quality, such drugs are often used to reduce the loss caused by stress.

Sedative

Xylazine hydrochloride is a class of drugs that eliminate restlessness and restore tranquility.

Biological activity

XylazineHCl is an alpha2 adrenergic receptor agonist used as a sedative and muscle relaxant.

 

In vivo studies

1. In beagle dogs, Xylazine hydrochloride dose-dependently inhibits the release of norepinephrine and lipolysis. Xylazine also tends to reduce epinephrine levels in a dose-dependent manner.

2. In horses, Xylazine dose- and time-dependently decreased minimum alveolar concentration (MAC) Xylazine hydrochloride dose- and time-dependently increased blood glucose concentration.

In horses, Xylazine significantly decreased heart rate, increased the incidence of atrioventricular block, and decreased cardiac output and cardiac index decline.

3. In standing mares, Xylazine induces variable bilateral caudal analgesia extending from the coccyx to S3 with minimal sedation, ataxia, and cardiorespiratory depression. Xylazine significantly reduces cardiac and respiratory rates, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, PCV, hemoglobin concentration, arterial blood oxygen content and oxygen delivery.

4. In dairy cows, Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours. Xylazine significantly reduces heart rate, respiratory rate, rumen contraction, arterial blood pressure, partial pressure of oxygen, PCV, and total solids concentration, and significantly increases PaCO2, alkali excess, and bicarbonate concentrations in dairy cows.

5. In brain-retomized rats without anesthesia, Xylazine inhibits the N3 field (-75%) and completely inhibits the climbing fiber field (-100%).

Related names

XYLAZINE HYDROCHLORIDE VETRANAL

XYLAZINE HYDROCHLORIDE, USPSTANDARD

XYLAZINE HYDROCHLORIDE, EPSTANDARD

XYLAZINE HYDROCHLORIDE, MM(CRMSTANDARD)

XYLAZINE HYDROCHLORIDE, IMP.A(EP):2,6-DIMETHYLANILINEMM(CRMSTANDARD)

2-[2,6-DIMETHYLPHENYLAMINO]-4H-5, 6-DIHYDROTHIAZINE HYDROCHLORIDE

2-[(2,6-DIMETHYLPHENYL)AMINO]-5, 6-DIHYDRO-4H-1, 3-THIAZINE HYDROCHLORIDE

2-(2,6-DIMETHYLPHENYLAMINO)-5, 6-DIHYDRO-4H-THIAZINE HYDROCHLORIDE

Related categories
Pharmaceutical raw materials; Thiazine; Other veterinary drug standard products; API raw materials; Veterinary drugs; Clinical standard products; Raw materials; Small molecule inhibitors; Raw materials; Xylazine hydrochloride; Chemical raw materials; Additives; Chemical industry; Building blocks; Analytical standards. Aromatics; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur&Selenium Compounds; Other APIs.
 

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