chemical
Introduction: Trenbolone (TRE) is a widely used steroid protein anabolic hormone, which is a chemically synthesized derivative similar in structure and activity to the human male hormone testosterone. It can promote protein synthesis, increase appetite, grow muscles, and promote the deposition of calcium and phosphorus in bone tissue. It can be clinically used to treat severe nutritional deficiencies and osteoporosis, but it is also the most frequently used type of exercise stimulant. Qunbolone cyclohexyl carbonate can be used as a synthetic intermediate for Qunbolone. The preparation of qunbolone cyclohexyl carbonate is as follows: under stirring and nitrogen atmosphere, 3g 17/3-hydroxy-estradiol 4,9,11-triene-3-one is dissolved in pyridine at 0 ℃ at 15 ℃. Maintain the temperature between 0 and 10 degrees Celsius. Slowly add 50ml of hexahydrobenzyl chloride Chemicalbook formate, then heat the entire mixture to ambient temperature, stir for 2 hours, and then cool to 0 ℃. Add triethylamine, stir for 30 minutes to raise the temperature to ambient temperature, and pour the reaction mixture into the water/ice mixture. Extract it with dichloromethane, wash the organic phase with water until neutral, dry with sodium sulfate, and evaporate under vacuum until dry. Chromatographically separate the residue on silica gel, elute with a 4:1 mixture of benzene/ethyl acetate, and recrystallize the product from the isopropyl ether/hexane mixture. Chromatographic separation was performed again on silica gel, eluted with a mixture of benzene/ethyl acetate and ethyl acetate, and finally recrystallized from cyclohexane and petroleum ether to obtain 1.60g of qunboron cyclohexyl carbonate. The product appears in a prism form that is soluble in ethanol, ether, benzene, acetone, and chloroform, but is insoluble in water, dilute acid, and alkaline aqueous solutions.