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99% Procaine Hydrochloride CAS 51-05-8 Local Anesthesia Drugs

 Product Name: Procaine hydrochloride
Synonyms: aminocaine;anadolor;anesthesol;anestil; ;Benzoicacid,monohydrochloride;benzoicacid,monohydrochloride;bernocaine
CAS: 51-05-8
MF: C13H21ClN2O2
MW: 272.77
EINECS: 200-077-2
Assay: 99%
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Description & Application:
The primary use for procaine is as a topical anaesthetic.
Procaine is used less frequently today since more effective (and hypoallergenic) alternatives such as (Xylocaine) exist. It has been discontinued from US markets.
 
Like other local anesthetics (such as mepivacaine, and prilocaine), procaine is a vasodilator, and is often coadministered with epinephrine for the purpose of vasoconstriction. Vasoconstriction helps to reduce bleeding, increases the duration and quality of anesthesia, prevents the drug from reaching systemic circulation in large amounts, and overall reduces the amount of anesthetic required.
Unlike  a vasoconstrictor, procaine does not have the euphoric and addictive qualities that put it at risk for abuse.  manufactures also use procaine as an additive at ratios ranging from 1:1 up to 10%  with 90% procaine, which can be life-threatening.
 
Procaine, an ester anesthetic, is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-amino benzoic acid (PABA), which is then excreted by the kidneys into the urine.
 
A 1% procaine injection has been recommended for the treatment of extravasation complications associated with venipuncture (along with moist heat, ASA, , antibiotics). It has likewise been recommended for treatment of inadvertent intra-arterial injections (10 ml of 1% procaine), as it helps relieve pain and vascular spasm.
 
Procaine is an occasional additive in illicit street drugs

Chemical Properties:

Small, colorless crystals or white, crystalline powder; odorless; stable in air. Soluble in water and in alcohol at 25C; slightly soluble in chloroform; almost insoluble in ether; solutions acid to litmus. Because the ester bond in the structure can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. Procaine hydrochloride has aromatic primary amino groups in its structure, which can be easily oxidized and discolored. pH, temperature, ultraviolet light, oxygen and metal ions can accelerate the oxidation and discoloration.

Local anesthetic:

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.